Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG
Identifieur interne : 000337 ( Main/Exploration ); précédent : 000336; suivant : 000338Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG
Auteurs : Oleg V. Pyankov [Russie] ; Yin Xiang Setoh [Australie] ; Sergey A. Bodnev [Russie] ; Judith H. Edmonds [Australie] ; Olga G. Pyankova [Russie] ; Stepan A. Pyankov [Russie] ; Gabor Pali [Australie] ; Shane Belford [Australie] ; Louis Lu [Australie] ; Mylinh La [Australie] ; George Lovrecz [Australie] ; Valentina A. Volchkova [France] ; Keith J. Chappell [Australie] ; Daniel Watterson [Australie] ; Glenn Marsh [Australie] ; Paul R. Young [Australie] ; Alexander A. Agafonov [Russie] ; Jillann F. Farmer [États-Unis] ; Victor E. Volchkov [France] ; Andreas Suhrbier [Australie] ; Alexander A. Khromykh [Australie]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
Herein we describe production of purified equine IgG obtained from horses immunized with plasmid DNA followed by boosting with Kunjin replicon virus-like particles both encoding a modified Ebola glycoprotein. Administration of the equine IgG over 5 days to cynomolgus macaques infected 24 hours previously with a lethal dose of Ebola virus suppressed viral loads by more than 5 logs and protected animals from mortality. Animals generated their own Ebola glycoprotein-specific IgG responses 9–15 days after infection, with circulating virus undetectable by day 15–17. Such equine IgG may find utility as a post-exposure prophylactic for Ebola infection and provides a low cost, scalable alternative to monoclonal antibodies, with extensive human safety data and WHO-standardized international manufacturing capability available in both high and low income countries.
Url:
DOI: 10.1038/srep41537
PubMed: 28155869
PubMed Central: 5290740
Affiliations:
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Pyankov</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Center for Virology and Biotechnology Vector</institution>, Koltsovo,<country>Russian Federation</country></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Setoh, Yin Xiang" sort="Setoh, Yin Xiang" uniqKey="Setoh Y" first="Yin Xiang" last="Setoh">Yin Xiang Setoh</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland</institution>, St Lucia, Brisbane, QLD,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bodnev, Sergey A" sort="Bodnev, Sergey A" uniqKey="Bodnev S" first="Sergey A." last="Bodnev">Sergey A. Bodnev</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Center for Virology and Biotechnology Vector</institution>, Koltsovo,<country>Russian Federation</country></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Edmonds, Judith H" sort="Edmonds, Judith H" uniqKey="Edmonds J" first="Judith H." last="Edmonds">Judith H. Edmonds</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland</institution>, St Lucia, Brisbane, QLD,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pyankova, Olga G" sort="Pyankova, Olga G" uniqKey="Pyankova O" first="Olga G." last="Pyankova">Olga G. Pyankova</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Center for Virology and Biotechnology Vector</institution>, Koltsovo,<country>Russian Federation</country></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pyankov, Stepan A" sort="Pyankov, Stepan A" uniqKey="Pyankov S" first="Stepan A." last="Pyankov">Stepan A. Pyankov</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Center for Virology and Biotechnology Vector</institution>, Koltsovo,<country>Russian Federation</country></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pali, Gabor" sort="Pali, Gabor" uniqKey="Pali G" first="Gabor" last="Pali">Gabor Pali</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland</institution>, St Lucia, Brisbane, QLD,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Belford, Shane" sort="Belford, Shane" uniqKey="Belford S" first="Shane" last="Belford">Shane Belford</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Plasvacc Pty. Ltd.</institution>, Kalbar, QLD,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lu, Louis" sort="Lu, Louis" uniqKey="Lu L" first="Louis" last="Lu">Louis Lu</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Bio Medical Manufacturing, Fermentation and Protein Production Facility</institution>, CSIRO, Clayton, VIC,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="La, Mylinh" sort="La, Mylinh" uniqKey="La M" first="Mylinh" last="La">Mylinh La</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Bio Medical Manufacturing, Fermentation and Protein Production Facility</institution>, CSIRO, Clayton, VIC,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lovrecz, George" sort="Lovrecz, George" uniqKey="Lovrecz G" first="George" last="Lovrecz">George Lovrecz</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Bio Medical Manufacturing, Fermentation and Protein Production Facility</institution>, CSIRO, Clayton, VIC,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Volchkova, Valentina A" sort="Volchkova, Valentina A" uniqKey="Volchkova V" first="Valentina A." last="Volchkova">Valentina A. Volchkova</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Molecular Basis of Viral Pathogenicity, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1</institution>, Ecole Normale Supérieure de Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chappell, Keith J" sort="Chappell, Keith J" uniqKey="Chappell K" first="Keith J." last="Chappell">Keith J. Chappell</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland</institution>, St Lucia, Brisbane, QLD,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Watterson, Daniel" sort="Watterson, Daniel" uniqKey="Watterson D" first="Daniel" last="Watterson">Daniel Watterson</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland</institution>, St Lucia, Brisbane, QLD,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marsh, Glenn" sort="Marsh, Glenn" uniqKey="Marsh G" first="Glenn" last="Marsh">Glenn Marsh</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>Australian Animal Health Laboratory, CSIRO Health and Biosecurity</institution>, Geelong, VIC,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Young, Paul R" sort="Young, Paul R" uniqKey="Young P" first="Paul R." last="Young">Paul R. Young</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland</institution>, St Lucia, Brisbane, QLD,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Agafonov, Alexander A" sort="Agafonov, Alexander A" uniqKey="Agafonov A" first="Alexander A." last="Agafonov">Alexander A. Agafonov</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>State Center for Virology and Biotechnology Vector</institution>, Koltsovo,<country>Russian Federation</country></nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Farmer, Jillann F" sort="Farmer, Jillann F" uniqKey="Farmer J" first="Jillann F." last="Farmer">Jillann F. Farmer</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>United Nations Medical Service</institution>, New York, NY 10017,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Volchkov, Victor E" sort="Volchkov, Victor E" uniqKey="Volchkov V" first="Victor E." last="Volchkov">Victor E. Volchkov</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Molecular Basis of Viral Pathogenicity, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1</institution>, Ecole Normale Supérieure de Lyon,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name><affiliation wicri:level="1"><nlm:aff id="a8"><institution>QIMR Berghofer Medical Research Institute</institution>, Brisbane, QLD,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khromykh, Alexander A" sort="Khromykh, Alexander A" uniqKey="Khromykh A" first="Alexander A." last="Khromykh">Alexander A. Khromykh</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland</institution>, St Lucia, Brisbane, QLD,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Herein we describe production of purified equine IgG obtained from horses immunized with plasmid DNA followed by boosting with Kunjin replicon virus-like particles both encoding a modified Ebola glycoprotein. Administration of the equine IgG over 5 days to cynomolgus macaques infected 24 hours previously with a lethal dose of Ebola virus suppressed viral loads by more than 5 logs and protected animals from mortality. Animals generated their own Ebola glycoprotein-specific IgG responses 9–15 days after infection, with circulating virus undetectable by day 15–17. Such equine IgG may find utility as a post-exposure prophylactic for Ebola infection and provides a low cost, scalable alternative to monoclonal antibodies, with extensive human safety data and WHO-standardized international manufacturing capability available in both high and low income countries.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cardile, A P" uniqKey="Cardile A">A. P. Cardile</name></author><author><name sortKey="Downey, L G" uniqKey="Downey L">L. G. Downey</name></author><author><name sortKey="Wiseman, P D" uniqKey="Wiseman P">P. D. 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Di Caro</name></author><author><name sortKey="Ippolito, G" uniqKey="Ippolito G">G. Ippolito</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Russie</li><li>États-Unis</li></country></list><tree><country name="Russie"><noRegion><name sortKey="Pyankov, Oleg V" sort="Pyankov, Oleg V" uniqKey="Pyankov O" first="Oleg V." last="Pyankov">Oleg V. Pyankov</name></noRegion><name sortKey="Agafonov, Alexander A" sort="Agafonov, Alexander A" uniqKey="Agafonov A" first="Alexander A." last="Agafonov">Alexander A. Agafonov</name><name sortKey="Bodnev, Sergey A" sort="Bodnev, Sergey A" uniqKey="Bodnev S" first="Sergey A." last="Bodnev">Sergey A. Bodnev</name><name sortKey="Pyankov, Stepan A" sort="Pyankov, Stepan A" uniqKey="Pyankov S" first="Stepan A." last="Pyankov">Stepan A. Pyankov</name><name sortKey="Pyankova, Olga G" sort="Pyankova, Olga G" uniqKey="Pyankova O" first="Olga G." last="Pyankova">Olga G. Pyankova</name></country><country name="Australie"><noRegion><name sortKey="Setoh, Yin Xiang" sort="Setoh, Yin Xiang" uniqKey="Setoh Y" first="Yin Xiang" last="Setoh">Yin Xiang Setoh</name></noRegion><name sortKey="Belford, Shane" sort="Belford, Shane" uniqKey="Belford S" first="Shane" last="Belford">Shane Belford</name><name sortKey="Chappell, Keith J" sort="Chappell, Keith J" uniqKey="Chappell K" first="Keith J." last="Chappell">Keith J. Chappell</name><name sortKey="Edmonds, Judith H" sort="Edmonds, Judith H" uniqKey="Edmonds J" first="Judith H." last="Edmonds">Judith H. Edmonds</name><name sortKey="Khromykh, Alexander A" sort="Khromykh, Alexander A" uniqKey="Khromykh A" first="Alexander A." last="Khromykh">Alexander A. Khromykh</name><name sortKey="La, Mylinh" sort="La, Mylinh" uniqKey="La M" first="Mylinh" last="La">Mylinh La</name><name sortKey="Lovrecz, George" sort="Lovrecz, George" uniqKey="Lovrecz G" first="George" last="Lovrecz">George Lovrecz</name><name sortKey="Lu, Louis" sort="Lu, Louis" uniqKey="Lu L" first="Louis" last="Lu">Louis Lu</name><name sortKey="Marsh, Glenn" sort="Marsh, Glenn" uniqKey="Marsh G" first="Glenn" last="Marsh">Glenn Marsh</name><name sortKey="Pali, Gabor" sort="Pali, Gabor" uniqKey="Pali G" first="Gabor" last="Pali">Gabor Pali</name><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name><name sortKey="Watterson, Daniel" sort="Watterson, Daniel" uniqKey="Watterson D" first="Daniel" last="Watterson">Daniel Watterson</name><name sortKey="Young, Paul R" sort="Young, Paul R" uniqKey="Young P" first="Paul R." last="Young">Paul R. Young</name></country><country name="France"><noRegion><name sortKey="Volchkova, Valentina A" sort="Volchkova, Valentina A" uniqKey="Volchkova V" first="Valentina A." last="Volchkova">Valentina A. Volchkova</name></noRegion><name sortKey="Volchkov, Victor E" sort="Volchkov, Victor E" uniqKey="Volchkov V" first="Victor E." last="Volchkov">Victor E. Volchkov</name></country><country name="États-Unis"><noRegion><name sortKey="Farmer, Jillann F" sort="Farmer, Jillann F" uniqKey="Farmer J" first="Jillann F." last="Farmer">Jillann F. Farmer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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